Quick answer: Berberine trials in people with type 2 diabetes, usually at 1,000 to 1,500 mg a day, found lower fasting glucose and HbA1c. It often causes stomach upset, interacts with many medicines and is not safe in pregnancy or breastfeeding.
How it works
Berberine activates AMPK, an enzyme that helps cells use glucose and reduces liver glucose output.
The evidence
Reviews show meaningful effects in type 2 diabetes, though many trials were small. NCCIH on berberine.
Side effects
- Cramps, constipation, diarrhea
- Low blood sugar with diabetes medicine
Interactions
It affects liver enzymes that process many drugs. Ask your pharmacist.
More GlycoZen guides
General information, not medical advice. GlycoZen is a dietary supplement and is not intended to diagnose, treat, cure or prevent any disease.